3D BASED ON 2D: CALCULATING HELIX ANGLES AND STACKING PATTERNS USING FORGI 2.0, AN RNA PYTHON LIBRARY CENTERED ON SECONDARY STRUCTURE ELEMENTS. [VERSION 2; PEER REVIEW: 2 APPROVED]

We present forgi, a Python library to analyze the tertiary structure of RNA secondary structure elements.Our representation of an RNA molecule is centered on secondary structure elements (stems, bulges and loops).By fitting a cylinder to the helix axis, these Multiminerals elements are carried over into a coarse-grained 3D structure representation.

After missing for seven days, a 34-year-old female was found with a rectal temperature of 19.8oC.Instead of attempting aggressive rewarming in the emergency department she was directly transferred to the operating room for extracorporeal rewarming.She received cardiopulmonary bypass (CPB) for 66 minutes Pocket Pillow at an initial warming rate of 1

Factors for initiating hibernation are unknown, but the condition shares some metabolic similarities with consciousness/sleep, which has been associated with n-3 fatty acids in humans.We investigated plasma phospholipid fatty acid profiles during hibernation and summer in free-ranging brown bears (Ursus arctos) and in captive garden dormice (Eliomy

ObjectiveThis study explored the effects of social support, illness perception, coping style, and vision-related quality of life (VRQOL) in older patients with dry eye disease (DED) using a chain mediation model.MethodsA total of 407 patients with DED from a tertiary hospital in Wuxi, Jiangsu Province, China, between June and December 2023 were sel

Skeletal muscle atrophy is a critical component of the ageing process.Age-related muscle wasting is due to disrupted muscle protein turnover, a process mediated in part by the ubiquitin proteasome pathway (UPP).Additionally, older subjects have been observed to have an attenuated anabolic response, at both the molecular and physiological levels, fo